TABLE 1.
Selected clinical trials and studies investigating outcome under oxygen therapy.
| Medical condition | Study/Trial | References | Outcome |
| Acute Respiratory Distress Syndrome (ARDS) | Data analysis from 10 RCTs | Aggarwal et al., 2018 (ARDS Network) | FiO2 > 0.5; PaO2 > 80 mmHg: increase of mortality in a dose-dependent manner |
| Multicenter RCT | Barrot et al., 2020 | Early exposure to conservative oxygenation strategy (paO2 = 55-70 mmHg) versus liberal oxygen therapy (paO2 = 90-105 mmHg) did not increase survival at 28 days | |
| Secondary analysis of LUNG SAFE study | Madotto et al., 2020 | No relationship between hyperoxemia and outcome | |
| Chronic Obstructive Pulmonary Disease (COPD) | LOTT | Long-Term Oxygen Treatment Trial Research Group et al., 2016 | No benefit for patients with stable COPD und moderate desaturations (mortality, time to hospitalization) |
| RCT | Austin et al., 2010 | Patients with acute excacerbations of COPD: titrated oxygen reduced mortality, hypercapnia and respiratory acidosis | |
| Myocardial Infarction (STEMI) | Cochrane Report | Cabello et al., 2013 | Need for better RCTs |
| AVOID | Stub et al., 2015 | Supplemental oxygen in patients with STEMI: no change in cardiac troponin, larger infarct size | |
| SOCCER | Khoshnood, 2018 | No benefit for normoxic STEMI patients; No change in infarct size, morbidity, mortality | |
| DETO2X Meta-analysis from 8 RCTs | Hofmann et al., 2017; Hofmann et al., 2018; Sepehrvand et al., 2018 | Suppl. Oxygen in normoxemic patients with STEMI does not reduce 1 year all cause mortality, STEMI-PCI: no significant effect on rehospitalization with MI, cardiogenic shock, stent thrombosis; No clinical benefit of supplemental O2 therapy | |
| Cardiac Arrest-Cardio-pulmonary Resuscitation (CA/CPR) | Multicenter study | Kilgannon et al., 2010 | Strong hyperoxemia (PaO2 > 300mmHg): increased in-hospital mortality |
| Colorectal surgery | PROXI | Meyhoff et al., 2009 | Slightly earlier reoccurrence of cancer, increased mortality |
| Meta-analysis of SSI studies | Podolyak et al., 2016 | Perioperative supplemental oxygen does increase long-term mortality of colorectal surgery patients | |
| Meta-analysis of PROXI | Fonnes et al., 2016 | Perioperative hyperoxia increased long-term risk of myocardial infarction and cardiovascular diseases | |
| Sepsis/Septic Shock | HYPER2S multi-center RCT | Asfar et al., 2017 | Adverse outcome in mechanically ventilated ICU patients; In patients with septic shock arterial hyperoxia increases risk of mortality |
| Stroke Traumatic brain injury | SOS RCT TRAUMOX1 | Roffe et al., 2017; Baekgaard et al., 2019 | No benefit of supplemental oxygen in patients with acute stroke; Recommends well designed conservative oxygen therapy |
| RCT | Taher et al., 2016 | Better outcome with liberal oxygen therapy |