FIGURE 2.

Up‐regulation of ROR1 decreased the expression of pro‐apoptosis genes (Bax, p53) in guinea pig cochlea but elevated the expression of anti‐apoptosis gene (Bcl‐2). Guinea pigs with NIHL were treated with ROR1 vector or empty vector. (A) the mRNA expression of ROR1, Bax, p53, Bcl‐2, Wnt5a and NF‐κB in cochlear tissues determined by RT‐qPCR. (B and C) the protein expression of ROR1, Bax, p53, Bcl‐2, Wnt5a and NF‐κB in cochlear tissues measured by Western blot analysis. The data are presented as a mean ± standard deviation. One‐way ANOVA is performed for multiple‐group comparison. ^* P < 0.05 vs. the normal group; ^# P < 0.05 vs. the empty vector group. n = 15