Figure 2.

Effects of atorvastatin, PCSK9 inhibitor and oestrogen on PCSK9 expression, LDLR expression in the heart tissue and cardiac function in ovariectomized prediabetic rats. A, PCSK9 expression; B, LDLR expression; C, systolic blood pressure; D, diastolic blood pressure; E, fractional shortening (%); F, mitral E/A ratio; G, LF/HF ratio; and H, MDA. *P < 0.05 vs NDS, ^† P < 0.05 vs HFS, ^‡ P < 0.05 vs HFOV. DBP, diastolic blood pressure; HFOA, high‐fat‐diet fed ovariectomized rats treated with atorvastatin; HFOE₂, high‐fat diet‐fed ovariectomized rats treated with oestrogen; HFOP, high‐fat diet‐fed ovariectomized rats treated with PCSK9 inhibitor; HFOV, high‐fat diet‐fed ovariectomized rats; HFS, high‐fat diet‐fed sham‐operated rats; LDLR, low‐density lipoprotein receptor; LF/HF ratio, low frequency/high frequency ratio; MDA, malondialdehyde; NDS, normal‐diet fed sham‐operated rats; PCSK9, proprotein convertase subtilisin/kexin type 9; SBP, systolic blood pressure