TABLE 1.
Cardiac morphology, haemodynamics and biochemistry at the end of study
| Parameters | Sham | Infarction | ||
|---|---|---|---|---|
| Saline | IPE | Vehicle | IPE | |
| No. of rats | 10 | 10 | 12 | 12 |
| Mortality, n (%) | 0 (0%) | 0 (0%) | 6 (33%) | 5 (29%) |
| Body weight, g | 352 ± 21 | 378 ± 18 | 349 ± 16 | 373 ± 18 |
| Heart rate, bpm | 398 ± 20 | 388 ± 19 | 403 ± 17 | 406 ± 17 |
| LVESP, mm Hg | 101 ± 5 | 102 ± 6 | 105 ± 8 | 107 ± 7 |
| LVEDP, mm Hg | 6 ± 1 | 5 ± 3 | 19 ± 4* | 17 ± 5* |
| +dp/dt, mm Hg/s | 6963 ± 364 | 7102 ± 376 | 2872 ± 342* | 3451 ± 304 * , † |
| −dp/dt, mm Hg/s | 6671 ± 337 | 6592 ± 392 | 2263 ± 296* | 2726 ± 318 * , † |
| Infarct size, % | … | … | 39 ± 3 | 40 ± 3 |
| LVW/BW, mg/g | 2.06 ± 0.21 | 2.22 ± 0.25 | 3.35 ± 0.39* | 3.29 ± 0.38* |
| RVW/BW, mg/g | 0.62 ± 0.12 | 0.65 ± 0.15 | 0.79 ± 0.11* | 0.69 ± 0.10 * , † |
| LungW/BW, mg/g | 4.22 ± 0.38 | 4.38 ± 0.29 | 5.98 ± 0.61* | 4.78 ± 0.45 * , † |
| Resolvin E1, pg/mL | 762 ± 142 | 19 877 ± 248 ‡ | 892 ± 172 | 21 634 ± 435 † |
Values are mean ± SD.
Abbreviations: BW, body weight; LungW, lung weight; LVEDP, left ventricular end‐diastolic pressure; LVESP, left ventricular end‐systolic pressure; LVW, left ventricular weight; RVW, right ventricular weight.
*
P < .05 compared with respective sham.
†
P < .05 compared with the infarcted group treated with vehicle.
‡
P < .05 compared with sham treated with saline.