Table 2.
Down- and up-regulated canonical pathway-related gene expression in the intestine of mice fed a high-fat diet (HFD), and effects of EGCG on these changes
| Canonical pathway | HFD vs Cont |
EGCG vs HFD |
|||
|---|---|---|---|---|---|
| Activation z-score | –Log (p value) | Activation z-score | –Log (p value) | ||
| Adenosine nucleotides degradation II | –2.0 | 2.5 | |||
| Apelin adipocyte signaling pathway | –2.3 | 1.8 | |||
| Cholesterol biosynthesis I | –2.0 | 2.5 | –2.2 | 3.5 | |
| Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | –2.0 | 2.5 | –2.2 | 3.5 | |
| Cholesterol biosynthesis III (via desmosterol) | –2.0 | 2.5 | –2.2 | 3.5 | |
| Cysteine biosynthesis III (mammalia) | –2.0 | 1.7 | |||
| EIF2 signaling | 5.1 | 30.3 | |||
| Glutathione-mediated detoxification | –2.4 | 3.1 | –2.4 | 3.1 | |
| Glycolysis I | –2.0 | 1.6 | |||
| NAD salvage pathway II | –2.0 | 1.7 | |||
| NRF2-mediated oxidative stress response | –2.4 | 3.6 | |||
| Oxidative phosphorylation | 2.5 | 1.6 | |||
| Sirtuin signaling pathway | –2.6 | 4.0 | 2.5 | 1.6 | |
| SPINK1 pancreatic cancer pathway | –2.8 | 7.5 | 2.8 | 7.6 | |
| Superpathway of cholesterol biosynthesis | –2.5 | 6.4 | |||
| Th1 pathway | –2.5 | 1.5 | |||
| Urate biosynthesis/inosine 5'-phosphate degradation | –2.0 | 2.5 | |||
| Valine degradation I | –2.0 | 2.0 | |||