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MTX concentration in the skin after administrating MTX Na by oral gavage and in the skin at the application site and 2.5 ± 0.5 cm away from the application site after applying MTX NC-MN. Data are reported as means ± S.D., n = 5.
| Time (h) | MTX concentration in the skin (µg/g) | ||
|---|---|---|---|
| MTX Oral | MTX NC-MN | ||
| MN application site | 2.5 ± 0.5 cm away from the MN application site | ||
| 2 | N/A | 624.51 ± 405.97 | 166.32 ± 136.13 |
| 24 | 0.942 ± 0.59 | 312.70 ± 161.95 | 45.69 ± 24.52 |
| 72 | 0.172± 0.09 | 78.27 ± 30.02 | 20.12 ± 8.88 |
