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. 2020 Aug 11;6:76. doi: 10.1038/s41420-020-00307-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Single-cell analysis of lung cancer cells (tumor) in EXP0068 and NC cells in SRA878024. b Single-cell analysis of oral cancer cells in GSE103322. c Single-cell analysis of ESCC cell line KYSE-180 (tumor) treated with different doses of radiotherapy in GSE81812. d Single-cell analysis of CG, WM, SM, and GC cells in GSE134520. e Single-cell analysis of colon cancer cells (tumor) and NC cells in GSE81861. Left column, UMAP plots showing the distribution of cells, color-coded for pathology; middle column, UMAP plots showing the distribution of ACE2-positive cell (red); right column, Stacked barplot showing the proportion of ACE2-positive cells (red). EXP0068 was downloaded from the Cancer Single-cell State Atlas; SRA878024 was downloaded from the PanglaoDB; GSE103322, GSE81812, GSE134520, and GSE81861 were obtained from the Gene Expression Omnibus. NC healthy normal control, ESCC esophageal squamous cell carcinoma, CG chronic gastritis, WM wild intestinal metaplasia, SM severe intestinal metaplasia, GC gastric cancer, UMAP Uniform Manifold Approximation and Projection, ACE2 angiotensin-converting enzyme 2.