Skip to main content
. 2020 Aug 4;11:1182. doi: 10.3389/fphar.2020.01182

Figure 5.

Figure 5

Effects of mexiletine (MEX) on late INa of mutant channels. Representative traces of late I Na recorded in the absence (a) or presence (b) of MEX (10 μM) at various depolarization voltages for N1325S (A), R1623Q (B), and M1652R (C) mutant channels, respectively. Summarized data of the percentage block of late I Na by MEX was presented in panel (c). Late I Na was recorded at 10 min after MEX application and measured at 200 ms after a voltage step from -90 to -20 mV. Control values (no MEX) of late I Na for N1325S, R1623Q, and M1652R were -1.33 ± 0.13, -1.22 ± 0.20, and -2.06 ± 0.21 pA/pF, respectively. N = 5–9. * P < 0.05 compared with control; †P < 0.05 compared with N1325S and R1623Q.