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The concentration-response relationships of drugs on late INa of mutant channels. A-C: Percentage inhibition of late INa in N1325S (A), R1623Q (B) and M1652R (C) mutant channels in absence (0) and presence of increased concentrations of drugs. Late INa was measured at 200 ms after a voltage step from -90 mV to -20 mV. ELE, eleclazine; RAN, ranolazine; MEX, mexiletine; LID, lidocaine; PRO, propranolol; MET, metoprolol; NAD, nadolol.
