Table 1.
Biophysical properties of mutant channels and inhibition of late INa by drugs.
| Activation | Inactivation | Recovery | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| V1/2 (mV) | Slope, κ (mV) | n | V1/2 (mV) | Slope, κ (mV) | n | A1 | τfast (ms) | τslow (ms) | n | |
| WT | -47.3 ± 1.0 | 4.8 ± 0.8 | 7 | -90.7 ± 1.8 | -12.9 ± 1.8 | 6 | 0.32 | 24.0 | 164.0 | 7 |
| N1325S(control) | -55.2 ± 0.5* | 4.1 ± 0.6 | 13 | -86.1 ± 1.3 | -14.3 ± 2.8 | 13 | 0.35 | 23.6 | 170.0 | 13 |
| N1325S(MEX) | -55.3 ± 0.5 | 4.9 ± 0.4 | 6 | -95.62 ± 0.5† | -10.6 ± 0.5 | 5 | 0.09 | 67.2† | 762.2† | 6 |
| R1623Q(control) | -49.6 ± 0.6 | 5.8 ± 0.6 | 7 | -105.9 ± 0.7* | -11.3 ± 0.6 | 6 | 0.16 | 35.3 | 2356.3 | 9 |
| R1623Q(MEX) | -51.7 ± 0.7 | 6.3 ± 0.7 | 6 | -110.0 ± 0.8† | -11.0 ± 0.7 | 6 | 0.16 | 52.3 | 5007.5† | 7 |
| M1652R(control) | -49.9 ± 0.8 | 4.4 ± 0.3 | 6 | -85.1 ± 1.0* | -14.4 ± 2.2 | 6 | 0.12 | 37.7 | 370.8 | 8 |
| M1652R(MEX) | -52.2 ± 0.7 | 5.6 ± 0.6 | 6 | -91.4 ± 2.0† | -16.0 ± 2.2 | 6 | 0.16 | 49.1 | 904.2† | 8 |
*P < 0.05 compared with WT; †P < 0.05 compared with control.