Table 5.

Pharmacokinetic parameters (ranges) of α‐solanine and α‐chaconine in human volunteers after oral exposure (adapted from Mensinga et al., 2005)

	GAs solution			GAs in mashed potatoes
Dose (mg/kg bw)	0.30	0.50	0.70	0.95	1.10	1.25
Number of subjects	2	2	2	3	3	2
α‐Chaconine
C max (μg/L)	2.8–3.2	3.2–4.5	3.3–6.3	5.2–7.4	2.9–7.8	6.3–9.7
T max (h)	5–6	5–6	4‐5	5–7	5‐8	7–12
T 1/2 (h)	32–37	49–84	29–39	27–49	49–60	37–45
AUC 0‐∞ (μg h/L)	117–130	148–242	128–227	237–345	168–316	299–419
α‐Solanine
C max (μg/L)	2.9–3.9	3.5–4.7	3.1–6.5	7.0–10.7	3.8–10.6	8.0–11.8
T max (h)	5–6	5–6	4–4	5–5	5–8	7–8
T 1/2 (h)	17–35	5–28	8–17	14–18	1–‐42	18–19
AUC 0‐∞ (μg h/L)	84–89	47–110	50–86	164–163	111–200	204–256