. 2020 Aug 11;18(8):e06222. doi: 10.2903/j.efsa.2020.6222

Table 6.

Acute toxicity in experimental animals: oral administration of glycoalkaloids (GAs) (α‐solanine) or mixtures, from edible parts of S. tuberosum

Test compounds	Species Dose route Doses	Observed effects	Highest dose with no effect (mg/kg bw)	Lowest dose with effect (mg/kg bw)	LD₅₀ (mg/kg bw)	Reference
α‐Solaninea	Sprague‐Dawley rats (M) No/sex/group: 5 Single gavage: 0, 20 or 250 mg/kg bw	–	250			Dalvi (1985)
α‐Solaninea	Albino mice (M) No/sex/group: n.r. Single oral application: 0 or 1,000 mg/kg bw	–	1,000			Nishie et al. (1971)
Mixture of α‐solanine and unknown proportion of α‐chaconineb	White rats (M/F) No/sex/group: 9 Single gavage: 300, 600 or 1,200 mg/kg bw	Diarrhoea Lethality		300	590	Gull (1960)

Test compounds

Species Dose route Doses

Observed effects

Highest dose with no effect (mg/kg bw)

Lowest dose with effect (mg/kg bw)

LD₅₀ (mg/kg bw)

Reference

α‐Solaninea

Sprague‐Dawley rats (M)

No/sex/group: 5

Single gavage: 0, 20 or 250 mg/kg bw

–

250

Dalvi (1985)

α‐Solaninea

Albino mice (M)

No/sex/group: n.r.

Single oral application: 0 or 1,000 mg/kg bw

–

1,000

Nishie et al. (1971)

Mixture of α‐solanine and unknown proportion of α‐chaconineb

White rats (M/F)

No/sex/group: 9

Single gavage: 300, 600 or 1,200 mg/kg bw

Diarrhoea

Lethality

300

590

Gull (1960)

F: females. M: males. n.r.: not reported.

Chemical standard obtained from a commercial supplier, with high purity (95% pure or higher).

Poorly characterised chemical standard (e.g. purity or composition not defined).