Table 8.
Acute toxicity in experimental animals: oral administration of glycoalkaloids (GAs) (α‐tomatine) from edible parts of S. lycopersicum and extracts from edible parts of S. melongena
| Substance (purity) | Species (sex) Dose route Doses | Observed effects | Highest dose with no effect (mg/kg bw) | Lowest dose with effect (mg/kg bw) | LD50 (mg/kg bw) | Reference |
|---|---|---|---|---|---|---|
| α‐Tomatinea |
Rats (M/F) No/sex/group: n.r. Oral dose of 900–1,000 mg/kg bw given within 24 h |
100% lethality | 900–1,000 | Wilson et al. (1961) | ||
| Water suspensions of ground lyophilised fruits of ripe S. melongena b |
Syrian hamster (sex n.r.) No/sex/group: 2 Single oral application: 6,316 mg suspension/kg bw TGA content of dried matter: 0.016% (corresponding to 1.0 mg TGA/kg bw) |
Haemorrhagic gastritis | 1 | Baker et al. (1989) |
F: females; M: males; n.r.: not reported.
a
Chemical standard obtained by in‐house isolation from plant material, may contain α‐dehydrotomatine as an impurity.
b
A non‐ or only partly purified extract or material for which the GA composition and concentration is given.