Table 16.

Reproductive toxicity studies on glycoalkaloids (GAs) (α‐solanine) from edible parts of S. tuberosum

Test compound	Species Experimental design Doses	Observed effects	Highest dose with no effect (mg/kg bw per day)		Lowest dose with effect (mg/kg bw per day)		Reference
			Mother	Offspring	Mother	Offspring
α‐Solanine
α‐Solanine (commercial)a α‐Solanine (isolated from sprouts)a	Female pregnant Holtzman rats N = 10/4 litters per group for testing of commercial/isolated α‐solanine Duration of exposure not clear (assumption that the study duration was 14 days) Diet: 0, 30, 40 mg α‐solanine (commercial) per kg chow (0, ≈ 3.6, ≈ 4.8 mg/kg bw per day) Diet: 0, 30 mg α‐solanine (isolated) per kg chow (≈ 3.6 mg/kg bw per day)	↑ number of litters in which pups died within the first 3 days ↓ percentage of weaned pups (37.5% weaned pups, compared to controls) ↓ percentage of weaned pups (23.6% weaned pups, compared to controls)				3.6 mg/kg bw per day (for commercial and isolated α‐solanine) 3.6 mg/kg bw per day (for commercial α‐solanine) 3.6 mg/kg bw per day (for isolated α‐solanine)	Kline et al. (1961)

^aPoorly characterised chemical standard (purity and composition not defined, may have contained α‐chaconine).