Table 17.

Reproductive toxicity studies on aglycones (solasodine) from edible parts of S. melongena

Test compound	Species Experimental design Doses	Observed effects	Lowest dose with effect (mg/kg bw per day)	Reference
Solasodine
Solasodinea	Captured Rhesus monkey (no further specifications) 0, 100 mg/kg bw per day for 150 days Oral administration by encapsulation into a banana On day 151 surgical removal of testes and epididymis	↓ testes weight ↓ epididymal weight ↓ seminiferous tubule diameter ↓ Leydig cell nuclei diameter ↓ spermatid count ↓ spermatozoa ↓ immature and mature Leydig cells ↓ sperm density and motility in cauda epididymis ↓ total protein, sialic acid, glycogen in testes ↑ cholesterol in testes	100 100 100 100 100 100 100 100 100 100	Dixit et al. (1989)
Solasodinea Isolated from berries of S. xanthocarpum	Dogs (M, 12–17 kg, 5 dogs per group) 0, 80 mg/kg bw per day Oral in a mutton meet pellet Duration: 30 days	↓ epididymal weight ↓ cauda epididymal epithelial height ↓ total protein, sialic acid, glycogen in the cauda epididymis ↑ cholesterol in the cauda epididymis	80 80 80 80	Gupta and Dixit (2002)

M: males.

^aChemical standard obtained by in‐house isolation from plant material, highly purified.