Table 21.
Acute oral toxicity of glycoalkaloids (GAs) (α‐solanine) and aglycones (solasodine) in ruminants
| Test compound | Species Dose route Doses | Observed effects | Highest dose with no effect (mg/kg bw) | Lowest dose with effects (mg/kg bw) | LD50 (mg/kg bw) | Reference |
|---|---|---|---|---|---|---|
| α‐Solanineb |
Sheep (F) No/sex/group: 1 Single oral dose: 100 or 225 mg/kg bw NO CONTROL |
Anisocytosis, poikilocytosis, leucocytosis | 225 | König and Staffe (1953) | ||
| α‐Solaninea |
Adolescent bull (M) No/sex/group: 1 Single gavage: 77 mg/kg bw NO CONTROL |
77 | Liebenow (1970) | |||
| Solasodinea |
Adolescent bull (M) No/sex/group: 1 Singe gavage: 43 mg/kg bw NO CONTROL |
43 | Liebenow (1970) |
F: female; M: male.
a
Chemical standard obtained by in‐house isolation from plant material, and checked for purity (95% pure or higher).
b
Poorly characterised chemical standard (purity or composition not defined, may contain α‐chaconine).