Table 24.
Repeated dose toxicity of potato protein concentrates in fish
| Test compound | Species Dose route Doses | Observed effects | Highest dose with no effect (mg/kg bw per day) | Lowest dose with effect (mg/kg bw per day) | Reference |
|---|---|---|---|---|---|
| Potato protein concentrate containing solanine at 1,000 mg/kg dwa |
Rainbow trout Application oral Control diet (fish meal) admixed with potato protein concentrate at isontrogenous and isoenergetic levels containing solanine at 0, 22, 56, 89 and 111 mg/kg diet (equivalent to: 0, 0.44, 1.12, 1.78 or 2.22 mg/kg bw per dayb) Duration: 28 days |
Specific growth rate | 0.44 | 1.12 | Xie and Jokumsen (1997) |
| Potato protein concentrate containing GA at 7.41 mg/kg dwa |
Rainbow trout Application oral Diet containing α‐solanine/α‐chaconine at 0/0, 0.4/0.6, 0.8/1.2, 1.2/1.7 or 1.6/2.3 mg/kg dw (equivalent to: 0/0, 0.008/0.012, 0.016/0.024, 0.024/0.034 or 0.032/0.048 mg/kg bw per dayb) Duration: 84 days |
↓ bw ↓Serum glucose ↓Serum protein Altered liver histology |
0.016/0.024 |
0.008/0.012 0.024/0.034 0.008/0.012 0.008/0.012 |
Tusche et al. (2011) |
| Potato protein concentrate containing GA at 2,150 mg/kg dwa |
Rainbow trout Application oral Diet containing α‐solanine/α‐chaconine at 0/0, 166/149, 306/298, 459/446 or 612/595 mg/kg dw (equivalent to: 0/0, 3.32/2.98, 6.12/5.96, 9.18/8.92, 12.24/11.9 mg/kg bw per dayb) Duration: 84 days |
↓ bw ↓Relative liver weight ↓Serum glucose and protein ↓Serum triglyceride Altered liver, intestinal and stomach histology |
3.32/2.98 3.32/2.98 3.32/2.98 3.32/2.98 3.32/2.98 |
Tusche et al. (2011) |
dw: dry weight; bw: body weight.
A non‐ or only partly purified extract or material for which the GA composition and concentration is given.
Body weight of 2 kg and average feed consumption of 40 g per day were assumed (EFSA, 2011c).