Table D.1.

Comparison of developmental toxicity of glycoalkaloids (GAs) and their aglycones from single dose studies

Compound	Dose (mmol/kg bw)	Dose (mg/kg bw)	Abnormal litters (%)	Abnormal fetuses (%)	Reference
Solanidine N‐oxide	0.14	58	0	0	Gaffield and Keeler (1996a,b)
Solanidine	0.29	115	19	2.3	Gaffield and Keeler (1996a,b)
Solanidine N‐oxide	0.29	120	0	0	Gaffield and Keeler (1996a,b)
Solanidine	0.43	175	50	16	Gaffield and Keeler (1996a,b); other study
Solanidine	0.44	176	50	24	Gaffield and Keeler (1993)
Demissidine	0.44	176	14	3	Gaffield and Keeler (1996a,b)
Demissidine	0.44	176	14	3	Gaffield and Keeler (1993)
Solanidine N‐oxide	0.43	178	50	16	Gaffield and Keeler (1996a,b)
α‐Chaconine	0.19	165	63	23	Renwick et al. (1984)
α‐Chaconine	0.21	179	20	2.7	Gaffield and Keeler (1996a,b)
α‐Chaconine	0.21	180	88	18	Renwick et al. (1984)
α‐Solanine	0.23	200	59	23	Renwick et al. (1984)
α‐Solanine	0.28	243	21	5.5	Gaffield and Keeler (1996a,b)
α‐Chaconine	0.29	247	Not measurable, maternal lethality	Not measurable, maternal lethality	Gaffield and Keeler (1996a,b)
Solasodine	3.4	1,400	75	29	Gaffield and Keeler (1993)
Dihydrosolasodine	3.4	1,400	45	6	Gaffield and Keeler (1993)