Table E.2.
Determined Ki values
Compound | Species | AChE | BuChE | |
---|---|---|---|---|
Ki (μM) | Ki (μM) | Citation | ||
α‐Solanine | Human plasma | 5 | Orgell (1963) | |
α‐Tomatine | Human plasma | 100 | ||
Chaconine (TLC preparation) | Purified bovine cholinesterase | 8,3 | Alozie et al. (1978) | |
Horse serum cholinesterase | 4 | |||
α‐Chaconine | equine BuChE | 1.39 | Benilova et al. (2006) | |
α‐Solanine | equine BuChE | 3.33 | ||
α‐Tomatine | equine BuChE | 1.66 | ||
α‐Chaconine | human BuChE | 0.17 | ||
α‐Solanine | human BuChE | 0.22 | ||
α‐Tomatine | human BuChE | 1.3 | ||
α‐Solanine | Human serum (D/D; wild type, homozygous) | 2.9 | Sternfeld et al. (1997) | |
α‐Solanine | Human serum (D/G; heterozygous) | 3.6 | ||
α‐Solanine | Human serum (G/G; homozygous) | 165 | ||
α‐Solanine | Human recombinant (D/D; wild type, homozygous) | 2.0 | ||
α‐Solanine | Human recombinant (D/G; heterozygous) | 3.5 | ||
α‐Solanine | Human recombinant (G/G; homozygous) | 171 | ||
α‐Solanine | Human, purified | 14 | 0.17 | McGehee et al. (2000) |
α‐Chaconine | Human, purified | 17 | 0.066 | |
α‐Solanine | Human wild type | 3.3 | Loewenstein‐Lichtenstein et al. (1996) | |
α‐Solanine | Human atypical (D70G) | 78 | ||
α‐Solanine | Various artificial mutations | 0.3–78 |