Fig. 1.

Sequence alignment between the serine protease domains of TMPRSS2 and TMPRSS15. The loop regions that were remodelled are highlighted by green bars. TMPRSS2 residues in the S4–S3–S2–S1–S1′-S2′-S3′-S4′ subsites are colored red. TMPRSS2 residues in the S1–S1′ subsites are further highlighted in bold. The lysine residue between the S2/S3 subsites is highlighted with a blue arrow. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article).