Table 2.
Human protein targets in the S1A serine protease family with structural data for approved, investigational or experimental drugs.
| Protein Name | UniProt ID | UniProt Gene Name | DrugBank Target ID |
|---|---|---|---|
| Apolipoprotein(a) | P08519 | APOA_HUMAN | 1283 |
| Cathepsin G | P08311 | CATG_HUMAN | 1010 |
| Chymase | P23946 | CMA1_HUMAN | 1038 |
| Coagulation factor IX | P00740 | FA9_HUMAN | 364 |
| Coagulation factor VII | P08709 | FA7_HUMAN | 333 |
| Coagulation factor X | P00742 | FA10_HUMAN | 216 |
| Coagulation factor XI | P03951 | FA11_HUMAN | 1021 |
| Coagulation factor XII | P00748 | FA12_HUMAN | 4672 |
| Complement C1r subcomponent | P00736 | C1R_HUMAN | 2093 |
| Complement C1s subcomponent | P09871 | C1S_HUMAN | 1529 |
| Complement factor B | P00751 | CFAB_HUMAN | 1701 |
| Complement factor D | P00746 | CFAD_HUMAN | 1840 |
| Complement factor I | P05156 | CFAI_HUMAN | 8979 |
| Haptoglobin | P00738 | HPT_HUMAN | 10,260 |
| Hepatocyte growth factor | P14210 | HGF_HUMAN | 1121 |
| Kallikrein-6 | Q92876 | KLK6_HUMAN | 1586 |
| Kallikrein-7 | P49862 | KLK7_HUMAN | 4150 |
| Myeloblastin | P24158 | PRTN3_HUMAN | 954 |
| Neutrophil elastase | P08246 | ELNE_HUMAN | 394 |
| Plasma kallikrein | P03952 | KLKB1_HUMAN | 2440 |
| Plasminogen | P00747 | PLMN_HUMAN | 211 |
| Prostasin | Q16651 | PRSS8_HUMAN | 3746 |
| Prostate-specific antigen | P07288 | KLK3_HUMAN | 8908 |
| Prothrombin | P00734 | THRB_HUMAN | 48 |
| Serine protease hepsin | P05981 | HEPS_HUMAN | 2128 |
| Tissue-type plasminogen activator | P00750 | TPA_HUMAN | 1088 |
| Trypsin-1 | P07477 | TRY1_HUMAN | 1739 |
| Trypsin-3 | P35030 | TRY3_HUMAN | 1583 |
| uPA | P00749 | UROK_HUMAN | 895 |
| Vitamin K-dependent protein C | P04070 | PROC_HUMAN | 380 |
| Vitamin K-dependent protein Z | P22891 | PROZ_HUMAN | 547 |