Table 2.
Effects of Different Concentrations of R. abyssinicus Crude Extract and Silymarin on Serum Biochemical Parameters
| Group | Dose | ALT (U/L) | AST (U/L) | ALP (U/L) |
|---|---|---|---|---|
| DW | 10 ml/kg | 44.7 ± 8.9 | 89.4 ± 9.8 | 92.8 ± 14.1 |
| CCl4 | 1 ml/kg | 145.3 ± 11.4b** | 226.7 ± 26.2b** | 236.3 ± 34.8b* |
| Silymarin + CCl4 | 100 mg/kg | 65.5 ± 7.5a** | 131.8 ± 11.5a* | 124.3 ± 21.5 |
| RA+ CCl4 | 125 mg/kg | 121.7 ± 9.3 | 226.7 ± 15.1 | 200.6 ± 27.8 |
| RA + CCl4 | 250 mg/kg | 97.6 ± 7.2a* | 195.4 ± 18.5 | 191.2 ± 25.0 |
| RA + CCl4 | 500 mg/kg | 93.7 ± 7.5a* | 125.2 ± 6.1a* | 144.7 ± 31.8 |
Notes: Data presented as mean ± S.E.M. aCompared to CCl4, bCompared with normal control (DW), *p< 0.01, **p< 0.001. One-way ANOVA followed by Tuckey test; n = 6.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; RA, Rumex abyssinicus; DW, distilled water; CCl4, carbon tetrachloride.