Table 3.
Effect of the 80% Methanolic Extract and Butanol Fraction Obtained from the Dried Rhizomes of R. abyssinicus and Silymarin Against CCl4-Induced Hepatotoxicity on Serum Biochemical Parameters
| Group | Dose | ALT (U/L) | AST (U/L) | ALP (U/L) |
|---|---|---|---|---|
| DW | 10 ml/kg | 67.2 ± 6.2 | 116.6 ± 11.1 | 128.2 ± 5.8 |
| CCl4 | 1ml/kg | 205.6 ± 28.1b** | 347.3 ±18.8b** | 359.8 ± 41.7b** |
| RA + CCl4 | 500 mg/kg | 106.8 ± 13a* | 232.6 ± 14.3a** | 231.6 ± 10.2a* |
| BU-RA + CCl4 | 500 mg/kg | 103 ±12.6a* | 211.1 ± 6.8a** | 224.1 ±3.3a* |
| Silymarin + CCl4 | 100 mg/kg | 97.1 ± 9.2a** | 220.1 ± 11.6a** | 180.4 ± 16.6a** |
Notes: Data presented as mean ± S.E.M. aCompared to CCl4, bCompared with normal control (DW), *p < 0.01, **p< 0.001. One-way ANOVA followed by Tuckey test; n = 6.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; RA, R. abyssinicus; BU-RA, butanol fraction of R. abyssinicus; DW, distilled water; CCl4, carbon tetrachloride.