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Schematic diagram of the functional mechanism of SNHGs. (A) SNHGs can promote or inhibit expression of downstream target genes. (B) Transcription factors (TF) bind to the promoter and activate transcription of SNHGs. SNHGs can then act as competing endogenous RNA sponges to regulate transcription of downstream target genes (ie TF), forming a positive feedback loop. SNHGs regulate promoter methylation (C) or acetylation (D) of downstream target genes and regulate tumor progression.
