Figure 9.
miR-203a-3p Ameliorates Liver Fibrosis in Mice
Mice were intraperitoneally injected with olive oil or CCl4 dissolved in olive oil combined with Ago-203 or Ago-NC. (A) Liver tissue sections stained with H&E (×200); n = 8. (B) Liver tissue sections stained with Masson (×200); n = 8. (C) Serum ALT and AST levels; n = 8. ∗∗p < 0.01 versus the Ago-NC group; ##p < 0.01 versus the CCl4 group. (D) miR-203a-3p expression in the liver; n = 3. ∗∗p < 0.01 versus the Ago-NC group; ##p < 0.01 versus the CCl4 group. (E-G) p66Shc, phosphorylated β-catenin, β-catenin, α-SMA and COL1A2 protein expression in the liver; n=3. ∗∗p < 0.01 versus the LV-control group; ##p < 0.01 versus the CCl4 group.