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. 2020 Aug 10;10:13487. doi: 10.1038/s41598-020-70366-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conservation and location of Ala595 in MBD6. (A) Multiple sequence alignment using Clustal-omega (EMBL-EBI) of the ATP7B protein showing the conservation status of the Ala595 residue among several mammalian species (Human, chimpanzee, cow, sheep, dog, rat,andmouse). (B) The structure of MBD6 (PDB accession 2EW9) with the Ala substituted with Thr using the mutagenesis function in PyMol. The difference in length of the Ala and Thr side chains are indicated in yellow.