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. 2020 Aug 10;10:13477. doi: 10.1038/s41598-020-68302-w

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome alteration in knee chondrocytes after Lipo-CGS21680 intraarticular treatment. Transcriptome analysis of articular chondrocytes isolated from PTOA rats. (A) Principal component analysis of RNA-seq expression data demonstrates distinct separation between healthy (unaffected knee), vehicle (empty liposomes) and Lipo-CGS21680-treated (Liposomes_CGS) groups. (B) 8 genes were upregulated and 42 were down-regulated in Lipo-CGS21680 group compare to the vehicle treated group (volcano plot). (C) Heatmap showing the first 50 genes alterated by Lipo or Lipo-CGS treatment.