Table 1.

Effects of SOCS-1 expression on brain metastasis in nude mice

Cell line	Brain metastasis
	Incidence*	Survival (d)†
A375Br	100.0% (11/11)	50 to 85
A375Br-Hygro	100.0% (10/10)	48 to 86
A375Br-SOCS-1-a	50.0% (4/8) ‡	67 to >120
A375Br-SOCS-1-b	44.4% (4/9) ‡	76 to >120
A375 Br-SOCS-1-c	22.2% (2/9) ‡	91 to >120

^*Percentage of mice with brain metastasis (number of positive mice / number of injected mice).

^†The survival time for brain tumor-free animal was recorded as 120 d.

^‡P < 0.001 compared with A375Br or A375-hygo control cells.