. Author manuscript; available in PMC: 2020 Aug 11.

Published in final edited form as: Crit Care Med. 2016 Sep;44(9):1744–1753. doi: 10.1097/CCM.0000000000001811

Table 4.

Association of Post-ICU Interventions with Depressive Symptoms

Post-ICU Interventions	Total	No Association		Negative Association (less depressive symptoms)
	N	N	%	N	%
Rehabilitation during post-ICU hospitalization	1	1	100%	0	0%
Physical Rehabilitation after discharge^a	3	1	0%	2	67%
Antidepressant +self-help manual vs antidepressant alone^b	1	0	0%	1	100%
ICU Diary	2	2	100%	0	0%
Nurse-led ICU follow-up clinic	1	1	100%	0	0%

Abbreviations: ICU: intensive care unit; N: number

^a:

In one RCT, physical rehab plus essential amino acid supplement was effective;

^b:

Self-help manual (rehabilitation package) alone reduced the rate of depressive symptoms but did not reach statistical significance (P=0.066)