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Effect of chloroquine on replication of canine coronavirus (CCoV) in canine fibrosarcoma A72 cells. Cells were preloaded with chloroquine for 1 h and infected with CCoV; the infectious titer (TCID50/ml) in supernatants was assessed in A72 cells. Data were analyzed by non-linear regression (95% confidence limits of the curve are shown). Adapted from [27]. TCID50 median tissue culture infectious dose, EC50 half maximal effective concentration, EC90 90% effective concentration
