| Hydroxychloroquine might impact the amplitude of the viral load peak and might also affect viral clearance if the drug is administered early enough when the virus is still confined to the pharyngeal cavity |
| Hydroxychloroquine's effects against SARS-CoV-2 might be exerted more through its capacity to enhance cell-mediated immunity than through its direct antiviral effects |
| The effects of hydroxychloroquine on SARS-CoV-2 viral load may thus be missed in clinical trials if measurements are not done at the peak of viral replication and are evident only at dosages able to guarantee a certain plasma drug concentration, i.e., > 400 mg/day |
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