Fig. 1.

Overlapping distribution of cohesin-STAG1 and cohesin-STAG2 on the genome. a Genome browser tracks showing ChIP-seq signal for STAG1, STAG2, RAD21, and CTCF (Z-score normalized). b Average signal plots of STAG1 and STAG2 signal at STAG1 peaks and STAG2 peaks (Z-score normalized). c Frequency of peaks overlapping known functional elements in the genome: CTCF sites, enhancers, promoters, or other (none of the above). d Clustered heatmaps displaying STAG1, STAG2, RAD21, and CTCF signal (Z-score normalized) at a union list of STAG1 and STAG2 peaks. e Western blot analysis following co-immunoprecipitation of SMC1, STAG1, and STAG2 from nuclear lysates