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. 2020 Aug 10;13:32. doi: 10.1186/s13072-020-00353-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Cohesin distribution is minimally changed in Stag1^−/− and Stag2^−/− mESCs. a Western blot analysis of cohesin subunit levels in wild-type, Stag1^−/−, and Stag2^−/− nuclear lysates. b Genome browser tracks showing STAG1 signal in wild-type and Stag2^−/− cells, and STAG2 signal in wild-type and Stag1^−/− cells. c MA plots showing differential enrichment of STAG1 signal between wild-type and Stag2^−/− cells. Differential enrichment of STAG2 signal between wild-type and Stag1^−/− cells is also shown. d Average signal plots of STAG1 signal at CTCF sites, enhancers, and promoters in wild-type and Stag2^−/− cells. STAG2 signal at CTCF sites, enhancers, and promoters in wild-type and Stag1^−/− cells is also shown. e Genome browser tracks showing RAD21 signal in wild-type, Stag1^−/−, and Stag2^−/− cells at Stag1^−/− and Stag2^−/− differential peaks. f MA plots showing differential enrichment of RAD21 in Stag1^−/− and Stag2^−/− cells. g Average signal plots of RAD21 signal at CTCF sites, enhancers, and promoters in wild-type, Stag1^−/−, and Stag2^−/− cells