Table 3.
Multivariate analysis with MLR‐LDH combination
| Variables | Training cohort | Validation cohort | Pooled cohort | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| Age, ≥70 vs.70 | 1.79 (1.11–2.86) | .016 | 1.38 (0.85–2.24) | .188 | 1.63 (1.18–2.25) | .003 |
| Sidedness, left vs. right | 0.62 (0.36–1.06) | .089 | 0.81 (0.51–1.29 | .387 | 0.75 (0.54–1.04) | .018 |
| Surgery of primary tumor, yes vs. no | 0.40 (0.24–0.68) | .001 | 0.97 (0.61–1.53) | .904 | 0.67 (0.49–0.94) | .089 |
| Pattern of metastasis | ||||||
| Lung vs. liver | 0.97 (0.47–1.96) | .933 | 1.42 (0.75–2.69) | .273 | 1.17 (0.76–1.82) | .466 |
| Nodes vs. liver | 1.29 (0.68–2.46) | .456 | 1.07 (0.52–2.23) | .839 | 1.29 (0.81–2.05) | .281 |
| Peritoneum vs. liver | 1.39 (0.78–2.44) | .254 | 3.06 (1.68–5.57) | <.001 | 1.97 (1.33–2.93) | .001 |
| BRAF, mutated vs. WT | 2.31 (1.08–4.91) | .029 | 1.37 (0.64–2.93) | .412 | 1.79 (1.06–3.02) | .028 |
| MLR‐LDH combination | ||||||
| MLR or LDH high vs. low | 2.74 (1.62–4.66) | <.001 | 1.86 (1.00–3.47) | .051 | 1.98 (1.38–2.86) | <.001 |
| MLR and LDH high vs. low | 3.73 (1.94–7.18) | <.001 | 4.46 (2.09–9.52) | <.001 | 3.42 (2.16–5.41) | <.001 |
| NLR, continuous variable | 1.00 (0.99–1.01) | .321 | 0.97 (0.88–1.06) | .527 | 1.00 (0.99–1.02) | .081 |
Bold values are statistically significant. Italicized text are values of reference.
Abbreviations: CI, confidence interval; HR, hazard ratio; LDH, lactate dehydrogenase; MLR, monocyte‐to‐lymphocyte ratio; NLR, neutrophil‐to‐lymphocyte ratio; WT, wild type.