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. 2020 Aug 6;14:3177–3188. doi: 10.2147/DDDT.S262121

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© 2020 Yang et al.

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Upregulating the interference of NRSF on MT’s in vitro protection. (A) Transfection efficiency of NRSF; (B) Upregulating NRSF eliminates inhibition of MT on neuronal apoptosis rate and its flow cytometry is here; (C–D) Upregulating NRSF eliminates the improvement of MT on autophagy factor protein level; (E–G) Upregulating NRSF eliminates the improvement of MT on inflammatory indexes; (H–J) Upregulating NRSF eliminates the improvement of MT on oxidative stress.

Notes: Compared with OGD/R or NC, **represents P<0.01; compared with OGD/R, *represents P<0.05; compared with OGD/R+MT, ^#represents P<0.05.

Abbreviations: MT, melatonin; NRSF, neuron-restrictive silencing factor; OGD/R, oxygen-glucose deprivation/reperfusion; NC, negative control; PI, propidium iodide; FITC, fluorescein isothiocyanate; LC3, light chain 3; P62, sequestosome 1; TNF, tumor necrosis factor; IL, interleukin; MDA, malondialdehyde; GSHPx, glutathione peroxidase; SOD, superoxide dismutase.