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. 2020 Aug 6;14:3177–3188. doi: 10.2147/DDDT.S262121

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© 2020 Yang et al.

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Effect of MT on JAK2-STAT3 pathway. (A) Effect of MT on the protein level of JAK2-STAT3 pathway marker and its protein map; (B) Effect of JAK2-STAT3 pathway inhibitor on MT antineuronal apoptosis and its cell flow diagram.

Notes: Compared with OGD/R, ^**represents P<0.01; compared with OGD/R+MT, ^#represents P<0.05.

Abbreviations: MT, melatonin; JAK2, Janus kinase-2; STAT3, signal transducer and activator of transcription-3; OGD/R, oxygen-glucose deprivation/reperfusion; PI, propidium iodide; FITC, fluorescein isothiocyanate; AG490, α-cyano-(3,4-hydroxy)N-benzylstyramine.