. 2020 Jul 29;20(4):59. doi: 10.3892/ol.2020.11920

Table V.

Univariate and multivariate analyses of prognostic factors for overall survival of patients with laryngeal squamous cell carcinoma.

	Univariate analysis			Multivariate analysis

Variables	HR	P-value	95% CI	HR	P-value	95% CI
Expression of MAGE-As, high vs. low	2.048	0.024^a	1.099-3.816
Expression of MAGE-A1, high vs. low	1.948	0.068	0.951-3.990
Expression of MAGE-A2, high vs. low	2.297	0.014^a	1.187-4.443	2.137	0.050	1.001-4.561
Expression of MAGE-A3, high vs. low	2.016	0.041^a	1.028-3.954	1.207	0.731	0.412-3.540
Expression of MAGE-A4, high vs. low	2.131	0.046^a	1.013-4.482	2.339	0.174	0.686-7.970
Expression of MAGE-A6, high vs. low	4.050	<0.001^a	1.958-8.376	1.410	0.480	0.543-3.665
Expression of MAGE-A9, high vs. low	3.204	<0.001^a	1.722-5.961	2.082	0.065	0.954-4.543
Expression of MAGE-A11, high vs. low	3.019	<0.001^a	1.636-5.573	2.438	0.032^a	1.080-5.504
Age, years, <60 vs. ≥60	1.369	0.327	0.730-2.566
Tumor location, supraglottic vs. glottic	1.839	0.053	0.992-3.409
Smoking index, <400 vs. ≥400	1.335	0.381	0.700-2.547
Tumor size, cm, <2 vs. ≥2	1.924	0.057	0.981-3.777
Histological grade, G1/G2 vs. G3	2.013	0.028^a	1.078-3.760	1.290	0.544	0.568-2.931
Clinical stage (AJCC), I/II vs. III/IV	2.345	0.013^a	1.194-4.604
Metastatic state of lymph node, N vs. N0	10.788	<0.001^a	5.036-23.110	21.112	<0.001^a	7.927-56.226

P<0.05. MAGE, melanoma-associated antigen; HR, hazard ratio; CI, confidence interval; N, patients with lymph node metastasis; AJCC, American Joint Committee on Cancer.