Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 29;20(4):57. doi: 10.3892/ol.2020.11918

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 1. — Erastin inhibits viability, induces death and activates autophagy in breast cancer cells. (A) MTT assay demonstrated that erastin inhibited the viability of MCF-7 and MDA-MB-231 breast cancer cells in a dose-dependent manner. (B) LDH release assay demonstrated that erastin enhanced breast cancer cell death in a dose-dependent manner. (C) Western blotting and (D) quantification demonstrated that erastin upregulated the expression levels of beclin1, ATG5, ATG12 and LC3B, and downregulated the expression of P62 in a time-dependent manner. *P<0.01 vs. control untreated group. ATG, autophagy related; LC3B, microtubule-associated proteins 1A/1B light chain 3B.