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The complex structure of presenilin homolog PSH bound to a hydroxyethylene derivative L-682679. (A) Structure of PSH bound to L-682679. The two catalytic aspartates D162 and D220 were shown in orange. L-682679 was shown in stick model with yellow for carbon, blue for nitrogen, red for oxygen (Dang et al., 2015). (B) Chemical structure of L-682679.
