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. 2020 Aug 11;8(1):e001508. doi: 10.1136/bmjdrc-2020-001508

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Intraislet and peripheral islet macrophages. (A) Immunofluorescence staining for insulin (INS) (red), CD68 (green) and 4′,6-diamidino-2-phenylindole (DAPI) (blue) in a patient with NGT. (B) Comparisons of the CD68⁺ cells per islet among the NGT, IGT, and DM groups. (C) Correlation coefficient between CD68⁺ cells per islet and parameters of age, BMI, HbA1c, FPG, CPR, C-peptide index, insulinogenic index, HOMA-IR, AUC_glucose, CRP, amylase and fat-cell area. Closed circles (●), the NGT group; open circles (○), the IGT group; closed triangles (▲), the DM group. AUC_glucose, area under the glucose concentration curve; BMI, body mass index; CPR, C-peptide immunoreactivity; CRP, C reactive protein; DM, diabetes mellitus; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; HOMA-IR, homeostasis model assessment insulin resistance; IGT, impaired glucose tolerance; NGT, normal glucose tolerance.