Table 1.

Characteristics of cases and controls

Characteristics	Cases, N (%)	Controls, N (%)
All	21 434	85 576
Demographics
Male sex (%)	10 277 (48)	41 010 (48)
Age, median (IQR)	71 (64 to 78)	71 (64 to 78)
History of mental disorders
Any psychiatric disease (%)	1549 (7)	4828 (6)
Schizophrenia (%)	74 (<1)	217 (<1)
Bipolar disease (%)	120 (1)	356 (<1)
Moderate-to-severe depression (%)	549 (3)	1742 (2)
Dementia (%)	122 (1)	366 (<1)
Other comorbidities
Acute kidney injury (%)	2436 (11)	2477 (3)
Diabetes (%)	3057 (14)	8138 (10)
Hypertension (%)	13 962 (65)	47 095 (55)
Antipsychotic exposure
Second-generation antipsychotics (%)	557 (3)	1731 (2)
Quetiapine (%)	173 (1)	504 (1)
Aripiprazole (%)	8 (<1)	41 (<1)
Risperidone (%)	299 (1)	967 (1)
Olanzapine (%)	220 (1)	593 (1)
Clozapine (%)	37 (<1)	82 (<1)
Exposure to other medications
Prior use of lithium (%)	210 (1)	563 (1)
Recent use of NSAIDs (%)	5610 (26)	20 081 (23)
Highest achieved level of education (%)
Level 1	10 250 (48)	38 385 (45)
Level 2	6785 (32)	27 778 (32)
Level 3	2687 (13)	12 727 (15)
Unknown	1712 (8)	6686 (8)

NSAIDs, non-steroidal anti-inflammatory drugs.