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a, Chemical structures of the three compounds in this study. b, Inhibition of purified native SARS-CoV-2 3CL protease by each compound. c, Inhibition of SARS-CoV-2 viral replication by each compound. Data are shown as mean ± s.e.m. for two or three technical replicates. IC50 and EC50 values are indicated as mean ± s.d. for two biological replicates.
