Figure 4: Genes related to Type I interferon signaling are upregulated in juvenile macaques compared to old macaques during COVID-19-infection.

The top 30 most significantly (A) upregulated genes and (B) downregulated genes in COVID-19 infected juvenile macaque lungs but not in old macaques. Expression values are visualized by Z scores of normalized expression data (FPKM) per sample, and Log₂ Fold Change and −Log P values are from the DESeq2 output. Genes are sorted by P value. (C) The relative gene expression of ACE2 and ADAM17 among naive, juvenile and old COVID-19 infected macaques.