Figure 6: Genes related to VEGF signaling are downregulated in old macaques compared to juvenile macaques during COVID-19.

The top 30 most significantly (A) upregulated genes and (B) downregulated genes in infected old macaque lungs but not in juvenile macaques. Expression values are visualized by Z scores of normalized expression data (FPKM) per sample, and Log₂ Fold Change and −Log P values are from the DESeq2 output. Genes are sorted by P value.