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letter
. 2020 Jul 11;10(3):e50. doi: 10.1002/ctm2.50

Figure 1.

Figure 1

Binding modes of Notopterol with BCAE1 (5CLM) and GSK3β (2OW3) and inhibiting the generation of Aβ and phosphorylated tau. A, Predicted conformation of Notopterol combined with BACE1. B, RMSD curve of Notopterol/BACE1 complex. C, Notopterol inhibited the activities of BACE1 enzyme. D, Predicted conformation of Notopterol combined with GSK3β E, RMSD curve of Notopterol/GSK3β complex. F, Notopterol inhibited the activities of GSK3β enzyme. G, The experimental protocol for measuring Aβ levels by enzyme linked immunosorbent assay (ELISA). H, Aβ40, Aβ42, and total Aβ in HEKAPPswe239T cells with or without Notopterol. I, Western blot of ADAM10, BACE1, and ADAM17 in APPswe239T cells. J, Western blot of p‐GSK3β, GSK3β, p‐tau, and tau in Okadaic acid‐treated SH‐SY5Y cells. The error bars represent the SD. (*P < 0.05, **P < 0.01 and ***P < 0.001, other comparisons were not significant; One‐way analysis of variance followed by Turkey's post hoc multiple‐comparisons test)