TABLE 1.

Clinical information of patients

	Number of patients			Number of patients
Variable	CD8+PD‐1_Plow	CD8+PD‐1_Phigh	P value	CD8+PD‐1_Tlow	CD8+PD‐1_Thigh	P value
Age
≤50 yr	71	24	.66	21	74	.321
> 50 yr	101	39		39	101
Sex
Female	30	11	.997	14	27	.164
male	142	52		46	148
HBsAg
Negative	31	4	.026	7	28	.416
Positive	141	59		53	147
TB
≤17 μmol/L	116	50	.075	38	128	.15
> 17 μmol/L	56	13		22	47
ALT
≤70 U/L	148	48	.072	49	147	.675
> 70 U/L	24	15		11	28
ALB
≤3.5 g/dl	9	1	.22	3	7	.741
> 3.5 g/dl	163	62		57	168
Preoperative AFP
≤20 ng/mL	60	23	.818	23	60	.571
> 20 ng/mL	112	40		37	115
Liver cirrhosis
No	25	15	.094	8	32	.378
Yes	147	48		52	143
Tumor size
≤5 cm	107	39	.966	41	105	.251
> 5 cm	65	24		19	70
Multinodular tumor
Single	144	53	.94	53	144	.272
Multiple	28	10		7	31
Edmondson‐Steiner
I‐II	131	46	.62	46	131	.779
III‐IV	41	17		14	44
γ‐GT
≤54	92	36	.618	39	89	.058
>54	80	27		21	86
BCLC stage
A	97	38	0.59	38	97	0.285
B+C	75	25		22	78
Vascular invasion
Absent	110	45	.284	38	117	.619
Present	62	18		22	58
Tumor encapsulation
Complete	91	34	.885	33	92	.745
None	81	29		27	83

A I‐value < .05 was considered statistically significant. P‐values were calculated using the Pearson chi‐square test.

Abbreviations: AFP, α‐fetoprotein; ALB, albumin; ALT, Alanine aminotransferase; BCLC stage, Barcelona clinic liver cancer stage; γ‐GT, γ‐glutamyl; HBsAg, hepatitis B surface antigen; TB, total bilirubin.