TABLE 3.
HLA-DRB1, DQB1 genotypes in various forms of sarcoidosis
| First author, year [ref.] | Patients with sarcoidosis and Löfgren's syndrome | Method of genotyping | The statistically approved HLA genotypes | Country | |
| Of predisposition | Protective | ||||
| Berlin, 1997 [33] | Sarcoidosis (n=122) | PCR-SSP | DRB1*03/17 | - | Scandinavia |
| Löfgren's syndrome (n=34) | DRB1*17 | - | |||
| Chronic form (n=57) | DR B1*14/15 | - | |||
| Bogunia-Kubik, 2001 [32] | Sarcoidosis (n=53) | PCR-SSP | DRB1*03 | DRB1*11 | Poland |
| Planck, 2002 [35] | Löfgren's syndrome (n=19) | PCR-SSP | DR B1*17 | - | Scandinavia |
| Foley, 2001 [36] | Sarcoidosis (n=345) | PCR-SSP | DRB1*03 | DRB1*01/04 | UK, Poland, Czech Republic |
| Grunewald, 2010 [37] | Sarcoidosis (n=724) | PCR-SSP | DRB1*03/14/15 | DRB1*01/03/07 | Scandinavia |
| Rossman, 2003 [38] | Sarcoidosis (n= 948) | PCR-SSP | DRB1*11.01/15.01/12.01 | DRB1*04.01/04.04/04.07/15.03 | USA |
| black | DRB1*11.01/1201 | DRB1*15.03 | |||
| white | DRB1*11.01/04.02/15.01 | DRB1*04.01 | |||
| Darlington, 2011 [39] | Patients with sarcoidosis (n=1000) out of whom had symptoms associated with HS (Heerfordt's syndrome) (n=83) | PCR-SSP | DRB1*04 - uveitis | DRB1*04 - system sarcoidosis | Sweden |
| Levin, 2015 [40] | Sarcoidosis (n=1277) | Illumina HumanOmni1-Quad | DRB1*12/11 | DRB1*03 | African Americans |
| da Costa, 2013 [41] | Sarcoidosis (n=63) | QuantiGene Plex assay | DRB1*14 | DRB1*15/16 | Brazil |
| Mortaz, 2015 [42] | Pulmonary sarcoidosis (n=51), Extrapulmonary sarcoidosis (n=39) | PCR-SSP | DRB1 *7 – pulmonary, DRB1 *12 - Extrapulmonary |
- | Iran |
| Ozyilmaz, 2014 [43] | Pulmonary sarcoidosis (n=86), Extrapulmonary sarcoidosis (n=46) | PCR-SSP | DRB1*15 | DRB1*11 - extrapulmonary | |
| Sharma, 2003 [44] | Sarcoidosis (n=56) | PCR-SSP | DRB1*11/14 (chronic form) | DRB1*07 | India |
| Voorter, 2005 [45] | Sarcoidosis (n=149) | PCR-SSP | DRB1*15.01/01 – severe form | - | Netherlands |
| Yanardag, 2017 [46] | Sarcoidosis (n=74) | PCR-SSP | DRB1*07/14/15 | - | Turkey |
| Papadopoulos, 2006 [47] | Sarcoidosis (n=66) | PCR-SSP | DRB1*02/14 | - | Germany |
HLA: human leukocyte antigen; PCR-SSP: single specific primer PCR.