. 2020 Aug 11;6(3):00359-2019. doi: 10.1183/23120541.00359-2019

TABLE 3.

Retrospectively collected data on asthma exacerbations, hospitalisation and emergency department admissions/visits

Study (year) [ref.]	Age range years	Study groups n	Exacerbation parameter(s)	Data for exacerbations by specified parameter, for each study group
Exacerbations reported in ≤6 months prior to study entry
Bateman et al. (2012) [25]	≥12	97, 100, 110, 95, 102, 94	Pts with ≥1 exacerbation in last 6 months	18%, 19%, 16%, 25%, 17%, 21%
McIvor et al. (2009) [22]^#	≥6	534	Patients with any exacerbation in 6 weeks prior to study entry	51.7%
Skoner et al. (2005) [57]	2–5	58, 51, 52, 50	No. of exacerbations in last 30 days	Mean: 1.8, 1.3, 1.5, 1.2 Median: 0,1,0, 0
Skoner et al. (2005) [57]	2–5	58, 51, 52, 50	Pts with ≥1 exacerbation in last 30 days	48.3%, 52.9%, 48.1%, 36.7%
Woodcock et al. (2002) [59]	18–65	86, 86	Mean no. daytime asthma attacks in 7-day run-in	0.25, 0.18
Woodcock et al. (2002) [59]	18–65	86, 86	Mean no. night-time asthma attacks in 7-day run-in	0.10, 0.10
Exacerbations reported in 12 months/1 year prior to study entry
Bateman et al. (2018) [26]	12–83	2089, 2087	Pts with 1 severe exacerbation in last 12 months	17.5%, 17.3%
			Pts with ≥1 severe exacerbations in last 12 months	22%, 21.9%
			Pts with ≥2 severe exacerbations in last 12 months	4.5%, 4.7%
Ding and Small (2017) [49]	≥12	524, 591	Pts with 1 exacerbation in last 12 months	9.0%, 13.1%
			Pts with ≥3 exacerbations in last 12 months	3.4%, 1.9%
			Mean (sd) no. of moderate-to-severe exacerbations in last 12 months	0.2 (0.6)^¶
			Mean (sd) no. of exacerbations treated in ED or hospital in last 12 months	0.1 (0.4), 0.1 (0.3)
			Mean (sd) no. of exacerbations treated with OCS, antibiotics, ED or hospital admission in last 12 months⁺	0.1 (0.5), 0.2 (0.6)
			Pts with 1 exacerbation treated with OCS, antibiotics, ED or hospital admission in last 12 months⁺	5.8%, 10.8%
			Pts with ≥3 exacerbations treated with OCS, antibiotics, ED or hospital admission in last 12 months⁺	1.0%, 1.5%
Giraud et al. (2006) [54]	≥18	94	Pts hospitalised for asthma in previous 12 months	4.3%
Herjavecz et al. (1999) [55]	17–67	90, 91	Time since last exacerbation	12.5 months, 13.0 months
Lai et al. (2003) [61]	Mean 7.4–40.5	1709, 633	Pts with hospital admissions in last year	7.3%, 15.4%
Lai et al. (2003) [61]	Mean 7.4–40.5	1709, 633	Pts with any hospital ED/unscheduled emergency visit in the last year	33.1%, 41.3%
Martinez et al. (2011) [36]	5–18	71, 72, 71,74	Mean no. hospital visits for asthma in last 1 year	0.3, 0.3, 0.2, 0.2
O’Byrne et al. (2018) [38]	≥12	1277, 1277,1282	Pts with ≥1 severe exacerbation in last 12 months	20.0%, 20.1%, 18.8%
Peters et al. (2007) [56]	≥6	166, 165, 169	Pts with ≥1 urgent visit for asthma in last 1 year	30.7%, 35.8%, 35.5%
Robertson et al. (2007) [21]^§	2–14	97, 105	Median no. of ED attendances for asthma in last 1 year	1, 1
Robertson et al. (2007) [21]^§	2–14	97, 105	Median no. of hospital admissions for asthma in last 1 year	1, 1
Soyer et al. (2009) [60]	6–18	522	Mean (sd) no. of unscheduled visits per patient	1.2 (0.2)
Soyer et al. (2009) [60]	6–18	522	Mean (sd) no. of ED visits per patient	0.6 (0.05)
Verbene et al. (1996) [58]	7–16	30	Pts hospitalised for asthma in last 1 year	0%

All studies were randomised controlled trials except Giraud et al. [54], McIvor et al. [22], Ding and Small [49], Lai et al. [61] and Soyer et al. [60]. pts: patients; ED: emergency department; OCS: oral corticosteroids; no.: number. ^# Study included patients with a history of exacerbations (time frame not specified); ^¶ n=1076; ⁺ time frame not specified in Results section of [49] although Methods section suggests 12-month timeframe; ^§: Study included only patients with a history of 3–6 exacerbations (hospitalisation or ED visit or general practitioner visits) in the 12 months prior to enrolment/screening.