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. 2020 Jul 6;76(3):953–961. doi: 10.1161/HYPERTENSIONAHA.120.15136

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© 2020 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 2. — Associations of genetically predicted mean arterial pressure (MAP) and pulse pressure (PP) across age deciles with risk of (A) ischemic stroke and (B) intracerebral hemorrhage. Effect sizes are derived from multivariable Mendelian randomization analyses adjusting for both genetically predicted MAP and PP in every decile. The analyses are based on the MEGASTROKE sample for ischemic stroke and on the ISGC sample for intracerebral hemorrhage. Trends across age were explored with linear meta-regression analyses. OR indicates odds ratio.