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. 2020 Aug 3;76(3):640–650. doi: 10.1161/HYPERTENSIONAHA.120.14742

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© 2020 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 5. — Pathological surge blood pressure (BP) detected by a new beat-by beat 'surge' BP monitoring and BP surge detection algorithm. A, Data showing suppression of BP surges trigged by apneic episodes during sleep in a 77-y-old woman with hypertension, diabetes mellitus, and obstructive sleep apnea. Sleep surge systolic (red dots) and diastolic (green dots) BP values were detected by the newly developed nocturnal beat-by-beat continuous BP monitoring (tonometry method) at baseline (treatment regimen: amlodipine 5 mg/d, aspirin 100 mg/d, and sitagliptin 25 mg/d) (left) and after 4 wk of add-on therapy with dapagliflozin 10 mg/d (right). B, The upper panels show the distribution of systolic BP (SBP) and diastolic BP (DBP) before (left) and after (right) 4 wk of dapagliflozin. The lower panels show nighttime BP surges detected by a newly developed surge autodetection algorithm.